About

The Instituto de Ciencia de Materiales de Madrid (ICMM) is an institute of the Consejo Superior de Investigaciones Cientificas (CSIC) (Spanish National Research Council) founded in December 1986, that belongs to the Area of Science and Technology of Materials, one of the eight Areas in which the CSIC divides its research activities.

 

Our mission is to create new fundamental and applied knowledge in materials of high technological impact, their processing and their transfer to the productive sectors at local, national and European scales (the true value of materials is in their use), the training of new professionals, and the dissemination of the scientific knowledge.

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Forthcoming Events

SEP09/12:00

Spin Dynamics in Inhomogeneously Magnetized Systems
Teruo Ono  read more

SEP16/12:00

Emergent Gauge fields and topological effects in Dirac matter
Yago Ferreiros Bas   read more

SEP19/12:00

Biomimetismo y Bioinspiracion: fuentes de conocimiento para innovar en Ciencia de Materiales

Clément Sanchez  read more

News

Una imagen en alta resolución se acerca a ‘la piel’ de Orión

Investigadores del grupo de Astrofísica Molecular del ICMM han obtenido la primera imagen en alta resolución del borde de la nube molecular de Orión

Descubierta una nueva relación en el comportamiento de los bosones, Gloria Platero y Mónica Benito del ICMM.



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Immunomodulatory and angiogenic responses induced by graphene oxide scaffolds in chronic spinal hemisected rats

Lopez-Dolado, E; Gonzalez-Mayorga, A; Gutierrez, MC; Serrano, MC

Attractive physic-chemical features of graphene oxide (GO) and promising results in vitro with neural cells encourage its exploration for biomedical applications including neural regeneration. Fueled by previous findings at the subacute state, we herein investigate for the first time chronic tissue responses (at 30 days) to 3D scaffolds composed of partially reduced GO (rGO) when implanted in the injured rat spinal cord. These studies aim to define fibrotic, inflammatory and angiogenic changes at the lesion site induced by the chronic implantation of these porous structures. Injured animals receiving no scaffolds show badly structured lesion zones and more cavities than those carrying rGO materials, thus pointing out a significant role of the scaffolds in injury stabilization and sealing. Notably, GFAP(+) cells and pro regenerative macrophages are evident at their interface. Moreover, rGO scaffolds support angiogenesis around and, more importantly, inside their structure, with abundant and functional new blood vessels in whose proximities inside the scaffolds some regenerated neuronal axons are found. On the contrary, lesion areas without rGO scaffolds show a diminished quantity of blood vessels and no axons at all. These findings provide a foundation for the usefulness of graphene-based materials in the design of novel biomaterials for spinal cord repair and encourage further investigation for the understanding of neural tissue responses to this kind of materials in vivo.

Biomaterials 99 (2016)

Representative immunofluorescence images of the lesion site at 30 days post-injury. Control samples are displayed on top for comparison. Bright field images are included to confirm location of the stained cells with respect to the scaffold. IF: interface; SC: scaffold. Scale bar: 100 μm. (For interpretation of the colors in this figure, the reader is referred to the web version of this article)

Publications Highlights

ICMM-2016 - Sor Juana Inés de la Cruz, 3, Cantoblanco, 28049 Madrid, Spain. Tel: +34 91 334 9000. Fax: +34 91 372 0623. info@icmm.csic.es